The old real estate slogan “location, location, location” now is being redefined by competition for talent and the growth of innovation. In recent years, companies like GE, McDonald’s, Caterpillar, Marriott, Kraft-Heinz foods, Google, and a hundred others have moved their offices to better attract talent. Research universities and hospitals can be the economic engines of a community. They are the places of innovation and the attractors of talent. The ingredients for success include an entrepreneurial culture within the institutions and the community generally, the ability to attract talent, venture funding for promising startups, a vibrant community where people want to live, and strong partnerships that bring together the institutional, political, civic, and business leadership to create the culture where talent thrives.